Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. La...
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| Format: | Online |
| Language: | English |
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The Rockefeller University Press
2001
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193523/ |
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pubmed-2193523 |
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pubmed-21935232008-04-14 Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia Rosenwald, Andreas Alizadeh, Ash A. Widhopf, George Simon, Richard Davis, R. Eric Yu, Xin Yang, Liming Pickeral, Oxana K. Rassenti, Laura Z. Powell, John Botstein, David Byrd, John C. Grever, Michael R. Cheson, Bruce D. Chiorazzi, Nicholas Wilson, Wyndham H. Kipps, Thomas J. Brown, Patrick O. Staudt, Louis M. Original Article The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. Lack of Ig mutations defined a distinctly worse prognostic group of CLL patients raising the possibility that CLL comprises two distinct diseases. Using genomic-scale gene expression profiling, we show that CLL is characterized by a common gene expression “signature,” irrespective of Ig mutational status, suggesting that CLL cases share a common mechanism of transformation and/or cell of origin. Nonetheless, the expression of hundreds of other genes correlated with the Ig mutational status, including many genes that are modulated in expression during mitogenic B cell receptor signaling. These genes were used to build a CLL subtype predictor that may help in the clinical classification of patients with this disease. The Rockefeller University Press 2001-12-03 /pmc/articles/PMC2193523/ /pubmed/11733578 Text en Copyright © 2001, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Rosenwald, Andreas Alizadeh, Ash A. Widhopf, George Simon, Richard Davis, R. Eric Yu, Xin Yang, Liming Pickeral, Oxana K. Rassenti, Laura Z. Powell, John Botstein, David Byrd, John C. Grever, Michael R. Cheson, Bruce D. Chiorazzi, Nicholas Wilson, Wyndham H. Kipps, Thomas J. Brown, Patrick O. Staudt, Louis M. |
| spellingShingle |
Rosenwald, Andreas Alizadeh, Ash A. Widhopf, George Simon, Richard Davis, R. Eric Yu, Xin Yang, Liming Pickeral, Oxana K. Rassenti, Laura Z. Powell, John Botstein, David Byrd, John C. Grever, Michael R. Cheson, Bruce D. Chiorazzi, Nicholas Wilson, Wyndham H. Kipps, Thomas J. Brown, Patrick O. Staudt, Louis M. Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia |
| author_facet |
Rosenwald, Andreas Alizadeh, Ash A. Widhopf, George Simon, Richard Davis, R. Eric Yu, Xin Yang, Liming Pickeral, Oxana K. Rassenti, Laura Z. Powell, John Botstein, David Byrd, John C. Grever, Michael R. Cheson, Bruce D. Chiorazzi, Nicholas Wilson, Wyndham H. Kipps, Thomas J. Brown, Patrick O. Staudt, Louis M. |
| author_sort |
Rosenwald, Andreas |
| title |
Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia |
| title_short |
Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia |
| title_full |
Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia |
| title_fullStr |
Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia |
| title_full_unstemmed |
Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia |
| title_sort |
relation of gene expression phenotype to immunoglobulin mutation genotype in b cell chronic lymphocytic leukemia |
| description |
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. Lack of Ig mutations defined a distinctly worse prognostic group of CLL patients raising the possibility that CLL comprises two distinct diseases. Using genomic-scale gene expression profiling, we show that CLL is characterized by a common gene expression “signature,” irrespective of Ig mutational status, suggesting that CLL cases share a common mechanism of transformation and/or cell of origin. Nonetheless, the expression of hundreds of other genes correlated with the Ig mutational status, including many genes that are modulated in expression during mitogenic B cell receptor signaling. These genes were used to build a CLL subtype predictor that may help in the clinical classification of patients with this disease. |
| publisher |
The Rockefeller University Press |
| publishDate |
2001 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193523/ |
| _version_ |
1611431145458630656 |