B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

Dendritic cells (DCs), unique antigen-presenting cells (APCs) with potent T cell stimulatory capacity, direct the activation and differentiation of T cells by providing costimulatory signals. As such, they are critical regulators of both natural and vaccine-induced immune responses. A new B7 family...

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Main Authors:	Tseng, Su-Yi, Otsuji, Mizuto, Gorski, Kevin, Huang, Xin, Slansky, Jill E., Pai, Sara I., Shalabi, Ahmed, Shin, Tahiro, Pardoll, Drew M., Tsuchiya, Haruo
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2001
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193370/

id	pubmed-2193370
recordtype	oai_dc
spelling	pubmed-21933702008-04-14 B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells Tseng, Su-Yi Otsuji, Mizuto Gorski, Kevin Huang, Xin Slansky, Jill E. Pai, Sara I. Shalabi, Ahmed Shin, Tahiro Pardoll, Drew M. Tsuchiya, Haruo Original Article Dendritic cells (DCs), unique antigen-presenting cells (APCs) with potent T cell stimulatory capacity, direct the activation and differentiation of T cells by providing costimulatory signals. As such, they are critical regulators of both natural and vaccine-induced immune responses. A new B7 family member, B7-DC, whose expression is highly restricted to DCs, was identified among a library of genes differentially expressed between DCs and activated macrophages. B7-DC fails to bind the B7.1/2 receptors CD28 and cytotoxic T lymphocyte–associated antigen (CTLA)-4, but does bind PD-1, a receptor for B7-H1/PD-L1. B7-DC costimulates T cell proliferation more efficiently than B7.1 and induces a distinct pattern of lymphokine secretion. In particular, B7-DC strongly costimulates interferon γ but not interleukin (IL)-4 or IL-10 production from isolated naive T cells. These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses. The Rockefeller University Press 2001-04-02 /pmc/articles/PMC2193370/ /pubmed/11283156 Text en © 2001 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tseng, Su-Yi Otsuji, Mizuto Gorski, Kevin Huang, Xin Slansky, Jill E. Pai, Sara I. Shalabi, Ahmed Shin, Tahiro Pardoll, Drew M. Tsuchiya, Haruo
spellingShingle	Tseng, Su-Yi Otsuji, Mizuto Gorski, Kevin Huang, Xin Slansky, Jill E. Pai, Sara I. Shalabi, Ahmed Shin, Tahiro Pardoll, Drew M. Tsuchiya, Haruo B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
author_facet	Tseng, Su-Yi Otsuji, Mizuto Gorski, Kevin Huang, Xin Slansky, Jill E. Pai, Sara I. Shalabi, Ahmed Shin, Tahiro Pardoll, Drew M. Tsuchiya, Haruo
author_sort	Tseng, Su-Yi
title	B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
title_short	B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
title_full	B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
title_fullStr	B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
title_full_unstemmed	B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
title_sort	b7-dc, a new dendritic cell molecule with potent costimulatory properties for t cells
description	Dendritic cells (DCs), unique antigen-presenting cells (APCs) with potent T cell stimulatory capacity, direct the activation and differentiation of T cells by providing costimulatory signals. As such, they are critical regulators of both natural and vaccine-induced immune responses. A new B7 family member, B7-DC, whose expression is highly restricted to DCs, was identified among a library of genes differentially expressed between DCs and activated macrophages. B7-DC fails to bind the B7.1/2 receptors CD28 and cytotoxic T lymphocyte–associated antigen (CTLA)-4, but does bind PD-1, a receptor for B7-H1/PD-L1. B7-DC costimulates T cell proliferation more efficiently than B7.1 and induces a distinct pattern of lymphokine secretion. In particular, B7-DC strongly costimulates interferon γ but not interleukin (IL)-4 or IL-10 production from isolated naive T cells. These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses.
publisher	The Rockefeller University Press
publishDate	2001
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193370/
_version_	1611431052742492160

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

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