An Alternative Open Reading Frame of the Human Macrophage Colony-Stimulating Factor Gene Is Independently Translated and Codes for an Antigenic Peptide of 14 Amino Acids Recognized by Tumor-Infiltrating Cd8 T Lymphocytes

An Alternative Open Reading Frame of the Human Macrophage Colony-Stimulating Factor Gene Is Independently Translated and Codes for an Antigenic Peptide of 14 Amino Acids Recognized by Tumor-Infiltrating Cd8 T Lymphocytes

We show that cytotoxic T lymphocytes (CTLs) infiltrating a kidney tumor recognize a peptide encoded by an alternative open reading frame (ORF) of the macrophage colony-stimulating factor (M-CSF) gene. Remarkably, this alternative ORF, which is translated in many tumors concurrently with the major OR...

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Bibliographic Details
Main Authors: Probst-Kepper, Michael, Stroobant, Vincent, Kridel, Robert, Gaugler, Béatrice, Landry, Claire, Brasseur, Francis, Cosyns, Jean-Pierre, Weynand, Birgit, Boon, Thierry, Van den Eynde, Benoit J.
Format: Online
Language:English
Published: The Rockefeller University Press 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193327/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193327/

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