Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate multiple autoimmune features. We report here that the ligand of PD-1 (PD-L1) is a member of the B7 gene family. Engageme...

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Bibliographic Details
Main Authors: Freeman, Gordon J., Long, Andrew J., Iwai, Yoshiko, Bourque, Karen, Chernova, Tatyana, Nishimura, Hiroyuki, Fitz, Lori J., Malenkovich, Nelly, Okazaki, Taku, Byrne, Michael C., Horton, Heidi F., Fouser, Lynette, Carter, Laura, Ling, Vincent, Bowman, Michael R., Carreno, Beatriz M., Collins, Mary, Wood, Clive R., Honjo, Tasuku
Format: Online
Language:English
Published: The Rockefeller University Press 2000
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193311/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193311/

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