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pubmed-2188701
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oai_dc
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pubmed-21887012008-04-17 Regulation of autoimmunity and donor cell engraftment by recipient Lyt- 2+ cells during the graft-versus-host reaction Articles When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE. To examine the role of recipient T cells in this process, BDF1 mice were depleted of L3T4+ or Lyt-2+ cells by thymectomy followed by treatment with mAbs to L3T4 or Lyt-2. This produced sustained depletion of these T cell subsets. Subsequent grafting with parental DBA/2 lymphocytes produced autoimmune disease in mice depleted of L3T4+ cells and controls but not in mice depleted of Lyt-2+ cells. Analysis of blood lymphocytes 4 wk after donor cell transfer demonstrated that BDF1 recipients depleted of Lyt- 2+ cells were virtually repopulated with donor T lymphocytes, compared with less than or equal to 35% donor cell engraftment in all other groups. Thus, recipient Lyt-2+ cells influence both host cell engraftment and autoimmunity during the parent-into-F1 GVHR. The Rockefeller University Press 1987-09-01 /pmc/articles/PMC2188701/ /pubmed/2957456 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
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| repository_type |
Open Access Journal
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| institution_category |
Foreign Institution
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| institution |
US National Center for Biotechnology Information
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| building |
NCBI PubMed
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| collection |
Online Access
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| language |
English
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| format |
Online
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| title |
Regulation of autoimmunity and donor cell engraftment by recipient Lyt- 2+ cells during the graft-versus-host reaction
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| spellingShingle |
Regulation of autoimmunity and donor cell engraftment by recipient Lyt- 2+ cells during the graft-versus-host reaction
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| title_short |
Regulation of autoimmunity and donor cell engraftment by recipient Lyt- 2+ cells during the graft-versus-host reaction
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| title_full |
Regulation of autoimmunity and donor cell engraftment by recipient Lyt- 2+ cells during the graft-versus-host reaction
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| title_fullStr |
Regulation of autoimmunity and donor cell engraftment by recipient Lyt- 2+ cells during the graft-versus-host reaction
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| title_full_unstemmed |
Regulation of autoimmunity and donor cell engraftment by recipient Lyt- 2+ cells during the graft-versus-host reaction
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| title_sort |
regulation of autoimmunity and donor cell engraftment by recipient lyt- 2+ cells during the graft-versus-host reaction
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| description |
When lymphocytes from DBA/2 mice are transferred to (C57BL X DBA/2)F1 (BDF1) mice, the ensuing graft-vs.-host reaction (GVHR) causes an autoimmune illness resembling human SLE. To examine the role of recipient T cells in this process, BDF1 mice were depleted of L3T4+ or Lyt-2+ cells by thymectomy followed by treatment with mAbs to L3T4 or Lyt-2. This produced sustained depletion of these T cell subsets. Subsequent grafting with parental DBA/2 lymphocytes produced autoimmune disease in mice depleted of L3T4+ cells and controls but not in mice depleted of Lyt-2+ cells. Analysis of blood lymphocytes 4 wk after donor cell transfer demonstrated that BDF1 recipients depleted of Lyt- 2+ cells were virtually repopulated with donor T lymphocytes, compared with less than or equal to 35% donor cell engraftment in all other groups. Thus, recipient Lyt-2+ cells influence both host cell engraftment and autoimmunity during the parent-into-F1 GVHR.
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| publisher |
The Rockefeller University Press
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| publishDate |
1987
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| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2188701/
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| _version_ |
1611428479771869184
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