Induction of murine autoimmune disease by chronic polyclonal B cell activation
In vivo, prolonged polyclonal activation of B cells by the nonantigenic but potent mitogenic lipid A portion of lipopolysaccharide (LPS-R595) resulted in acceleration of the late life systemic lupus erythematosus disease of female MRL/n, BXSB, and NZW mice, mimicking the time, form, and histopatholo...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1983
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186966/ |