Mutant monoclonal antibodies with alterations in biological functions
Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states a...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
1982
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186830/ |
| Summary: | Somatic cell mutants with deletions in the immunoglobulin constant region were isolated from an IgG(2b) Ar-binding hybridoma. Rat anti-mouse immunoglobulins were used to identify the sites of the deletions. The mutant monoclonal antibodies differ from the parental molecule in their assembly states and are defective in various immunoglobulin activities, making them potentially more useful reagents. |
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