B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells
During ontogeny IgD appears later than IgM on splenocytes of neonatal mice (1) and at a time when mice develop a markedly increased immune responsiveness (2). Based on these observations, it was suggested that IgD serves as a “triggering” isotype for induction of immune responses, whereas surface Ig...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
1977
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2181918/ |