Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells
Phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) on serine 51 is effected by specific stress-activated protein kinases. eIF2α phosphorylation inhibits translation initiation promoting a cytoprotective gene expression program known as the integrated stress response (ISR). Stress...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2003
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173671/ |