Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs

Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs

The DNA repair proteins poly(ADP-ribose) polymerase-1 (PARP-1), Ku86, and catalytic subunit of DNA-PK (DNA-PKcs) have been involved in telomere metabolism. To genetically dissect the impact of these activities on telomere function, as well as organismal cancer and aging, we have generated mice doubl...

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Bibliographic Details
Main Authors: Espejel, Silvia, Klatt, Peter, Murcia, Josiane Ménissier-de, Martín-Caballero, Juan, Flores, Juana M., Taccioli, Guillermo, de Murcia, Gilbert, Blasco, María A.
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172587/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172587/

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