Stress-induced transcription of satellite III repeats

Stress-induced transcription of satellite III repeats

Exposure of mammalian cells to stress induces the activation of heat shock transcription factor 1 (HSF1) and the subsequent transcription of heat shock genes. Activation of the heat shock response also correlates with a rapid relocalization of HSF1 within a few nuclear structures termed nuclear stre...

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Main Authors: Jolly, Caroline, Metz, Alexandra, Govin, Jérôme, Vigneron, Marc, Turner, Bryan M., Khochbin, Saadi, Vourc'h, Claire
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171959/
id pubmed-2171959
recordtype oai_dc
spelling pubmed-21719592008-03-05 Stress-induced transcription of satellite III repeats Jolly, Caroline Metz, Alexandra Govin, Jérôme Vigneron, Marc Turner, Bryan M. Khochbin, Saadi Vourc'h, Claire Article Exposure of mammalian cells to stress induces the activation of heat shock transcription factor 1 (HSF1) and the subsequent transcription of heat shock genes. Activation of the heat shock response also correlates with a rapid relocalization of HSF1 within a few nuclear structures termed nuclear stress granules. These stress-induced structures, which form primarily on the 9q12 region in humans through direct binding of HSF1 to satellite III repeats, do not colocalize with transcription sites of known hsp genes. In this paper, we show that nuclear stress granules correspond to RNA polymerase II transcription factories where satellite III repeats are transcribed into large and stable RNAs that remain associated with the 9q12 region, even throughout mitosis. This work not only reveals the existence of a new major heat-induced transcript in human cells that may play a role in chromatin structure, but also provides evidence for a transcriptional activity within a locus considered so far as heterochromatic and silent. The Rockefeller University Press 2004-01-05 /pmc/articles/PMC2171959/ /pubmed/14699086 http://dx.doi.org/10.1083/jcb.200306104 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Jolly, Caroline
Metz, Alexandra
Govin, Jérôme
Vigneron, Marc
Turner, Bryan M.
Khochbin, Saadi
Vourc'h, Claire
spellingShingle Jolly, Caroline
Metz, Alexandra
Govin, Jérôme
Vigneron, Marc
Turner, Bryan M.
Khochbin, Saadi
Vourc'h, Claire
Stress-induced transcription of satellite III repeats
author_facet Jolly, Caroline
Metz, Alexandra
Govin, Jérôme
Vigneron, Marc
Turner, Bryan M.
Khochbin, Saadi
Vourc'h, Claire
author_sort Jolly, Caroline
title Stress-induced transcription of satellite III repeats
title_short Stress-induced transcription of satellite III repeats
title_full Stress-induced transcription of satellite III repeats
title_fullStr Stress-induced transcription of satellite III repeats
title_full_unstemmed Stress-induced transcription of satellite III repeats
title_sort stress-induced transcription of satellite iii repeats
description Exposure of mammalian cells to stress induces the activation of heat shock transcription factor 1 (HSF1) and the subsequent transcription of heat shock genes. Activation of the heat shock response also correlates with a rapid relocalization of HSF1 within a few nuclear structures termed nuclear stress granules. These stress-induced structures, which form primarily on the 9q12 region in humans through direct binding of HSF1 to satellite III repeats, do not colocalize with transcription sites of known hsp genes. In this paper, we show that nuclear stress granules correspond to RNA polymerase II transcription factories where satellite III repeats are transcribed into large and stable RNAs that remain associated with the 9q12 region, even throughout mitosis. This work not only reveals the existence of a new major heat-induced transcript in human cells that may play a role in chromatin structure, but also provides evidence for a transcriptional activity within a locus considered so far as heterochromatic and silent.
publisher The Rockefeller University Press
publishDate 2004
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171959/
_version_ 1611424765181952000

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