HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock

HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock

A full response to heat shock depends on the duration of HSF1 activation, which is controlled by the deacetylase HDAC6, known to bind ubiquitin residues, and by AAA ATPase p97/VCP. This new regulatory process relies on the extent of protein ubiquitination and directs the ability of cells to remain p...

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Bibliographic Details
Main Authors: Pernet, Lydia, Faure, Virginie, Gilquin, Benoit, Dufour-Guérin, Solenne, Khochbin, Saadi, Vourc’h, Claire
Format: Online
Language:English
Published: The American Society for Cell Biology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263459/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263459/

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