eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′UTR
The eukaryotic translation initiation factor eIF4E is a critical modulator of cellular growth with functions in the nucleus and cytoplasm. In the cytoplasm, recognition of the 5′ m7G cap moiety on all mRNAs is sufficient for their functional interaction with eIF4E. In contrast, we have shown that in...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2005
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171863/ |