Differential var gene expression in the organs of patients dying of falciparum malaria

Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, m...

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Main Authors:	Montgomery, Jacqui, Mphande, Fingani A, Berriman, Matthew, Pain, Arnab, Rogerson, Stephen J, Taylor, Terrie E, Molyneux, Malcolm E, Craig, Alister
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170262/

id	pubmed-2170262
recordtype	oai_dc
spelling	pubmed-21702622008-01-03 Differential var gene expression in the organs of patients dying of falciparum malaria Montgomery, Jacqui Mphande, Fingani A Berriman, Matthew Pain, Arnab Rogerson, Stephen J Taylor, Terrie E Molyneux, Malcolm E Craig, Alister Research Articles Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, mediates cytoadherence to vascular endothelium. To address the question of tissue-specific accumulation of variant types, we used the unique resource generated by the clinicopathological study of fatal paediatric malaria in Blantyre, Malawi, to analyse var gene transcription in patients dying with falciparum malaria. Despite up to 102 different var genes being expressed by P. falciparum populations in a single host, only one to two of these genes were expressed at high levels in the brains and hearts of these patients. These major var types differed between organs. However, identical var types were expressed in the brains of multiple patients from a single malaria season. These results provide the first evidence of organ-specific accumulation of P. falciparum variant types and suggest that parasitized erythrocytes can exhibit preferential binding in the body, supporting the hypothesis of cytoadherence-linked pathogenesis. Blackwell Publishing Ltd 2007-08 /pmc/articles/PMC2170262/ /pubmed/17617167 http://dx.doi.org/10.1111/j.1365-2958.2007.05837.x Text en © 2007 Liverpool School of Tropical Medicine; Journal compilation © 2007 Blackwell Publishing Ltd
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Montgomery, Jacqui Mphande, Fingani A Berriman, Matthew Pain, Arnab Rogerson, Stephen J Taylor, Terrie E Molyneux, Malcolm E Craig, Alister
spellingShingle	Montgomery, Jacqui Mphande, Fingani A Berriman, Matthew Pain, Arnab Rogerson, Stephen J Taylor, Terrie E Molyneux, Malcolm E Craig, Alister Differential var gene expression in the organs of patients dying of falciparum malaria
author_facet	Montgomery, Jacqui Mphande, Fingani A Berriman, Matthew Pain, Arnab Rogerson, Stephen J Taylor, Terrie E Molyneux, Malcolm E Craig, Alister
author_sort	Montgomery, Jacqui
title	Differential var gene expression in the organs of patients dying of falciparum malaria
title_short	Differential var gene expression in the organs of patients dying of falciparum malaria
title_full	Differential var gene expression in the organs of patients dying of falciparum malaria
title_fullStr	Differential var gene expression in the organs of patients dying of falciparum malaria
title_full_unstemmed	Differential var gene expression in the organs of patients dying of falciparum malaria
title_sort	differential var gene expression in the organs of patients dying of falciparum malaria
description	Sequestration of parasitized erythrocytes in the microcirculation of tissues is thought to be important in the pathogenesis of severe falciparum malaria. A major variant surface antigen, var/Plasmodium falciparum erythrocyte membrane protein 1, expressed on the surface of the infected erythrocyte, mediates cytoadherence to vascular endothelium. To address the question of tissue-specific accumulation of variant types, we used the unique resource generated by the clinicopathological study of fatal paediatric malaria in Blantyre, Malawi, to analyse var gene transcription in patients dying with falciparum malaria. Despite up to 102 different var genes being expressed by P. falciparum populations in a single host, only one to two of these genes were expressed at high levels in the brains and hearts of these patients. These major var types differed between organs. However, identical var types were expressed in the brains of multiple patients from a single malaria season. These results provide the first evidence of organ-specific accumulation of P. falciparum variant types and suggest that parasitized erythrocytes can exhibit preferential binding in the body, supporting the hypothesis of cytoadherence-linked pathogenesis.
publisher	Blackwell Publishing Ltd
publishDate	2007
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170262/
_version_	1611424507182972928

Differential var gene expression in the organs of patients dying of falciparum malaria

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