Suppression of tumorigenic and metastatic potentials of human melanoma cell lines by mutated (143 Val-Ala) p53.
Metastatic melanoma, compared with other cancers, appears to be unusual because of its low frequency of p53 mutations and prevalence of wild-type p53 protein in advanced malignancy. Here, we examined the effects of wild-type and mutated p53 (143 Val-Ala) on tumorigenic and metastatic potential of tw...
Main Authors: | , , , |
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Format: | Online |
Language: | English |
Published: |
Nature Publishing Group
1998
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150410/ |