A Structured-based Model for the Decreased Activity of Ala222Val and Glu429Ala Methylenetetrahydrofolate Reductase (MTHFR) Mutants
The structure of human Methylenetetrahydrofolate Reductase (MTHFR) is not known either by NMR or by X-ray methods. Phosphorylation seems to play an important role in the functioning of this flavoprotein. MTHFR catalyzes an irreversible reaction in homocysteine metabolism. Phosphorylation decreases t...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Biomedical Informatics
2013
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842580/ |