Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence
During biosynthesis, MHC class II-invariant chain complexes are transported into endosomal compartments where invariant chain (Ii) is degraded and class II encounters antigenic peptides. One of the signals that determines this intracellular transport route has been localized to the cytosolic domain...
| Format: | Online |
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| Language: | English |
| Published: |
The Rockefeller University Press
1995
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120468/ |