| id |
pubmed-2119441
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| recordtype |
oai_dc
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| spelling |
pubmed-21194412008-04-16 Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition Articles Small peptides, derived from endogenous proteins bind within the antigen binding groove created by the beta-pleated sheets and alpha helices of the alpha 1 and alpha 2 domains of the class I molecule of the major histocompatibility complex (MHC). However, the precise role of peptide in class I MHC conformation remains unclear. Here, we have shown that, in at least some instances, changes induced in the MHC molecule by the binding of distinct peptides can be identified as specific alterations in serological epitopes expressed on the class I protein. The nature of specific peptides expressed by class I-bearing cells may, therefore, have a dramatic influence on T cell development, self-tolerance, and alloreactivity. The Rockefeller University Press 1992-12-01 /pmc/articles/PMC2119441/ /pubmed/1460430 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
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| repository_type |
Open Access Journal
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| institution_category |
Foreign Institution
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| institution |
US National Center for Biotechnology Information
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| building |
NCBI PubMed
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| collection |
Online Access
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| language |
English
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| format |
Online
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| title |
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition
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| spellingShingle |
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition
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| title_short |
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition
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| title_full |
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition
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| title_fullStr |
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition
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| title_full_unstemmed |
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition
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| title_sort |
peptide-induced conformational changes in class i heavy chains alter major histocompatibility complex recognition
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| description |
Small peptides, derived from endogenous proteins bind within the antigen binding groove created by the beta-pleated sheets and alpha helices of the alpha 1 and alpha 2 domains of the class I molecule of the major histocompatibility complex (MHC). However, the precise role of peptide in class I MHC conformation remains unclear. Here, we have shown that, in at least some instances, changes induced in the MHC molecule by the binding of distinct peptides can be identified as specific alterations in serological epitopes expressed on the class I protein. The nature of specific peptides expressed by class I-bearing cells may, therefore, have a dramatic influence on T cell development, self-tolerance, and alloreactivity.
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| publisher |
The Rockefeller University Press
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| publishDate |
1992
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| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119441/
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| _version_ |
1611415353631440896
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