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pubmed-2119307
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| recordtype |
oai_dc
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pubmed-21193072008-04-16 Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes Articles Most mice display two conventional major histocompatibility complex class II isotypes, A and E. Several A+E- strains have been observed, but never any that are A-E+. Because of this and because of hints from several lines of functional analysis, it has been proposed that the two isotypes might not operate equivalently. This proposition has not been directly testable until now because of the lack of an E-only strain. We report the production of such mice, exploiting previously created class II-transgenic and class II-"knock-out" lines. A+E-, A-E-, and A-E+ littermates have been compared by a number of parameters. We find that E and A molecules are, for the most part, functionally equivalent. However, subtle differences are seen in their ability to engage CD4 molecules on immature thymocytes, and in the profile of receptors on T cells selected into the periphery. The Rockefeller University Press 1992-08-01 /pmc/articles/PMC2119307/ /pubmed/1500864 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
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| repository_type |
Open Access Journal
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| institution_category |
Foreign Institution
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| institution |
US National Center for Biotechnology Information
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| building |
NCBI PubMed
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| collection |
Online Access
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| language |
English
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| format |
Online
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| title |
Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes
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| spellingShingle |
Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes
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| title_short |
Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes
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| title_full |
Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes
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| title_fullStr |
Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes
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| title_full_unstemmed |
Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes
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| title_sort |
evaluation of the functional equivalence of major histocompatibility complex class ii a and e complexes
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| description |
Most mice display two conventional major histocompatibility complex class II isotypes, A and E. Several A+E- strains have been observed, but never any that are A-E+. Because of this and because of hints from several lines of functional analysis, it has been proposed that the two isotypes might not operate equivalently. This proposition has not been directly testable until now because of the lack of an E-only strain. We report the production of such mice, exploiting previously created class II-transgenic and class II-"knock-out" lines. A+E-, A-E-, and A-E+ littermates have been compared by a number of parameters. We find that E and A molecules are, for the most part, functionally equivalent. However, subtle differences are seen in their ability to engage CD4 molecules on immature thymocytes, and in the profile of receptors on T cells selected into the periphery.
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| publisher |
The Rockefeller University Press
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| publishDate |
1992
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| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119307/
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| _version_ |
1611415272775745536
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