The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Recent studies have shown that activating mutations of NOTCH1 are responsible for the majority of T cell acute lymphoblastic leukemia (T-ALL) cases. Most of these mutations truncate its C-terminal domain, a region that is important for the NOTCH1 proteasome-mediated degradation. We report that the E...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2007
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118676/ |