Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL
Oncogenic mutations in NOTCH1 are present in over 50% of T-cell lymphoblastic leukemias (T-ALLs). Activation of NOTCH1 requires a double proteolytic processing in the extracellular region of the receptor (S2) and in the transmembrane domain (S3). Currently, anti-NOTCH1 therapies based on inhibition...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165074/ |