Establishment of a retinoic acid-resistant human acute promyelocytic leukaemia (APL) model in human granulocyte-macrophage colony-stimulating factor (hGM-CSF) transgenic severe combined immunodeficiency (SCID) mice.

Establishment of a retinoic acid-resistant human acute promyelocytic leukaemia (APL) model in human granulocyte-macrophage colony-stimulating factor (hGM-CSF) transgenic severe combined immunodeficiency (SCID) mice.

To understand the mechanisms and identify novel approaches to overcoming retinoic acid (RA) resistance in acute promyelocytic leukaemia (APL), we established the first human RA-resistant APL model in severe combined immunodeficiency (SCID) mice. UF-1 cells, an RA-resistant APL cell line established...

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Bibliographic Details
Main Authors: Fukuchi, Y., Kizaki, M., Kinjo, K., Awaya, N., Muto, A., Ito, M., Kawai, Y., Umezawa, A., Hata, J., Ueyama, Y., Ikeda, Y.
Format: Online
Language:English
Published: Nature Publishing Group|1 1998
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063129/

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