Establishment of a Humanized APL Model via the Transplantation of PML-RARA-Transduced Human Common Myeloid Progenitors into Immunodeficient Mice

Establishment of a Humanized APL Model via the Transplantation of PML-RARA-Transduced Human Common Myeloid Progenitors into Immunodeficient Mice

Recent advances in cancer biology have revealed that many malignancies possess a hierarchal system, and leukemic stem cells (LSC) or leukemia-initiating cells (LIC) appear to be obligatory for disease progression. Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia characterized...

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Bibliographic Details
Main Authors: Matsushita, Hiromichi, Yahata, Takashi, Sheng, Yin, Nakamura, Yoshihiko, Muguruma, Yukari, Matsuzawa, Hideyuki, Tanaka, Masayuki, Hayashi, Hideki, Sato, Tadayuki, Damdinsuren, Anar, Onizuka, Makoto, Ito, Mamoru, Miyachi, Hayato, Pandolfi, Pier Paolo, Ando, Kiyoshi
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219701/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219701/

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