Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.
We have investigated the effect of misonidazole (MISO) on the pharmacokinetics of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in mice. CCNU and its monohydroxylated metabolites were measured using a high performance liquid chromatography (HPLC) method. In the absence of MISO the plasma disap...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
1983
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2011404/ |