A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No signi...
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| Format: | Online |
| Language: | English |
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1981
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010639/ |
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pubmed-2010639 |
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oai_dc |
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pubmed-20106392009-09-10 A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. Bleehen, N. M. Wiltshire, C. R. Plowman, P. N. Watson, J. V. Gleave, J. R. Holmes, A. E. Lewin, W. S. Treip, C. S. Hawkins, T. D. Research Article The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail. 1981-04 /pmc/articles/PMC2010639/ /pubmed/7016157 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Bleehen, N. M. Wiltshire, C. R. Plowman, P. N. Watson, J. V. Gleave, J. R. Holmes, A. E. Lewin, W. S. Treip, C. S. Hawkins, T. D. |
| spellingShingle |
Bleehen, N. M. Wiltshire, C. R. Plowman, P. N. Watson, J. V. Gleave, J. R. Holmes, A. E. Lewin, W. S. Treip, C. S. Hawkins, T. D. A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. |
| author_facet |
Bleehen, N. M. Wiltshire, C. R. Plowman, P. N. Watson, J. V. Gleave, J. R. Holmes, A. E. Lewin, W. S. Treip, C. S. Hawkins, T. D. |
| author_sort |
Bleehen, N. M. |
| title |
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. |
| title_short |
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. |
| title_full |
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. |
| title_fullStr |
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. |
| title_full_unstemmed |
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. |
| title_sort |
randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma. |
| description |
The results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail. |
| publishDate |
1981 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2010639/ |
| _version_ |
1611403699243974656 |