Phase I and pharmacokinetic study of D-verapamil and doxorubicin.
The calcium antagonist verapamil (a mixture of D- and L-racemers) is a potent modulator of the multi-drug resistance phenotype in vitro at a concentration of 6 microM. Clinical studies have shown dose-limiting toxicity of hypotension and heart block when plasma levels approach the concentrations act...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
1991
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977847/ |