Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells.
Cyclosporin A (Sandimmune) rapidly induced an increase in daunorubicin accumulation in multidrug-resistant human ovarian carcinoma cells (2780AD) and was more potent than verapamil. Steady-state 3H-cyclosporin A accumulation at 37 degrees C in 2780AD cells was 60-70% of that in the sensitive A2780 c...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
1990
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971735/ |