Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells.
The p53 gene is a growth control gene, abnormalities of which have been implicated in a variety of cancers. Recently wild-type p53 has been shown to exist in two interchangeable conformational variants, which can be distinguished by specific p53 monoclonal antibodies. One conformation acts as a supp...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
1994
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968850/ |