Enhancement of sensitivity to platinum(II)-containing drugs by 12-O-tetradecanoyl-phorbol-13-acetate in a human ovarian carcinoma cell line.
Sensitivity to platinum-containing drugs is believed to be a function of how much drug enters the cell, the extent of DNA adduct formation and the rate at which DNA is repaired. Activation of protein kinase C by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was found to enhance the sensitivity of huma...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1994
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968705/ |