A Mycobacterium ESX-1–Secreted Virulence Factor with Unique Requirements for Export

A Mycobacterium ESX-1–Secreted Virulence Factor with Unique Requirements for Export

Specialized secretion systems of pathogenic bacteria commonly transport multiple effectors that act in concert to control and exploit the host cell as a replication-permissive niche. Both the Mycobacterium marinum and the Mycobacterium tuberculosis genomes contain an extended region of difference 1...

Full description

Bibliographic Details
Main Authors:	McLaughlin, Bryant, Chon, Janet S, MacGurn, Jason A, Carlsson, Fredric, Cheng, Terri L, Cox, Jeffery S, Brown, Eric J
Format:	Online
Language:	English
Published:	Public Library of Science 2007
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1937011/

Similar Items

The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis
by: Serafini, Agnese, et al.
Published: (2013)

Modular Organization of the ESX-5 Secretion System in Mycobacterium tuberculosis
by: Shah, Swati, et al.
Published: (2016)

Solution Structure of the Mycobacterium tuberculosis EsxG·EsxH Complex: FUNCTIONAL IMPLICATIONS AND COMPARISONS WITH OTHER M. TUBERCULOSIS Esx FAMILY COMPLEXES*
by: Ilghari, Dariush, et al.
Published: (2011)

The ESX System in Bacillus subtilis Mediates Protein Secretion
by: Huppert, Laura A., et al.
Published: (2014)

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes
by: van Winden, Vincent J. C., et al.
Published: (2016)

The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress
by: Zhao, Yingying, et al.
Published: (2013)

Computational Analysis of the ESX-1 Region of Mycobacterium tuberculosis: Insights into the Mechanism of Type VII Secretion System
by: Das, Chandrani, et al.
Published: (2011)

Correction: The ESX-3 Secretion System Is Necessary for Iron and Zinc Homeostasis in Mycobacterium tuberculosis
by: Serafini, Agnese, et al.
Published: (2014)

Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
by: Mehra, Alka, et al.
Published: (2013)

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF.
by: Trang H Phan, et al.
Published: (2018-08-01)

ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans☆
by: Hingley-Wilson, Suzanne M., et al.
Published: (2014)

The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems
by: Newton-Foot, Mae, et al.
Published: (2016)

M. tuberculosis Ser/Thr Protein Kinase D Phosphorylates an Anti-Anti–Sigma Factor Homolog
by: Greenstein, Andrew E, et al.
Published: (2007)

Mycobacterium tuberculosis RNA Expression Patterns in Sputum Bacteria Indicate Secreted Esx Factors Contributing to Growth are Highly Expressed in Active Disease
by: Bukka, Archana, et al.
Published: (2012)

ESAT-6 (EsxA) and TB10.4 (EsxH) Based Vaccines for Pre- and Post-Exposure Tuberculosis Vaccination
by: Hoang, Truc, et al.
Published: (2013)

Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis
by: Wells, Ryan M., et al.
Published: (2013)

Interaction between Polyketide Synthase and Transporter Suggests Coupled Synthesis and Export of Virulence Lipid in M. tuberculosis
by: Jain, Madhulika, et al.
Published: (2005)

Revealing the mechanisms of membrane protein export by virulence-associated bacterial secretion systems
by: Lea Krampen, et al.
Published: (2018-08-01)

EsxA might as a virulence factor induce antibodies in patients with Staphylococcus aureus infection
by: Zhou, Huiqin, et al.
Published: (2013)

The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10
by: Ates, Louis S., et al.
Published: (2016)

Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
by: Gey van Pittius, Nicolaas C, et al.
Published: (2006)

The ESX-5 Associated eccB5-eccC5 Locus Is Essential for Mycobacterium tuberculosis Viability
by: Di Luca, Mariagrazia, et al.
Published: (2012)

Two promoters in the esx-3 gene cluster of Mycobacterium smegmatis respond inversely to different iron concentrations in vitro
by: Zhuo Fang, et al.
Published: (2017-08-01)

Live attenuated Salmonella typhimurium vaccines delivering SaEsxA and SaEsxB via type III secretion system confer protection against Staphylococcus aureus infection
by: Chen Xu, et al.
Published: (2018-04-01)

Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
by: Chen, Jeffrey M.
Published: (2016)

EsxB, a secreted protein from Bacillus anthracis forms two distinct helical bundles
by: Fan, Yao, et al.
Published: (2015)

Correction: Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria
Published: (2015)

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria
by: Ates, Louis S., et al.
Published: (2015)

MYCOBACTERIUM TUBERCULOSIS VIRULENCE
by: B. I. Vishnevskiy, et al.
Published: (2014-01-01)

ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question
by: Aguiló, Nacho, et al.
Published: (2013)

Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition
by: Siegrist, M. Sloan, et al.
Published: (2014)

EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5
by: Zhang, Qi, et al.
Published: (2016)

Overexpression of a Mycobacterium ulcerans Ag85B-EsxH Fusion Protein in Recombinant BCG Improves Experimental Buruli Ulcer Vaccine Efficacy.
by: Bryan E Hart, et al.
Published: (2016-12-01)

Overexpression of a Mycobacterium ulcerans Ag85B-EsxH Fusion Protein in Recombinant BCG Improves Experimental Buruli Ulcer Vaccine Efficacy
by: Hart, Bryan E., et al.
Published: (2016)

Whole genome SNP analysis suggests unique virulence factor differences of the Beijing and Manila families of Mycobacterium tuberculosis found in Hawaii.
by: Kent Koster, et al.

Virulence factors of the Mycobacterium tuberculosis complex
by: Forrellad, Marina A., et al.
Published: (2013)

Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system
by: Wagner, Jonathan M., et al.
Published: (2016)

Lipid metabolism and Type VII secretion systems dominate the genome scale virulence profile of Mycobacterium tuberculosis in human dendritic cells
by: Mendum, Tom A, et al.
Published: (2015)

Increased Virulence of an Epidemic Strain of Mycobacterium massiliense in Mice
by: Shang, Shaobin, et al.
Published: (2011)

Deciphering the virulence factors of the opportunistic pathogen Mycobacterium colombiense
by: Gonzalez-Perez, M.N., et al.
Published: (2016)