A real-time view of the TAR:Tat:P-TEFb complex at HIV-1 transcription sites
HIV-1 transcription is tightly regulated: silent in long-term latency and highly active in acutely-infected cells. Transcription is activated by the viral protein Tat, which recruits the elongation factor P-TEFb by binding the TAR sequence present in nascent HIV-1 RNAs. In this study, we analyzed th...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904240/ |