Specificity, duplex degradation and subcellular localization of antagomirs

Specificity, duplex degradation and subcellular localization of antagomirs

MicroRNAs (miRNAs) are an abundant class of 20–23-nt long regulators of gene expression. The study of miRNA function in mice and potential therapeutic approaches largely depend on modified oligonucleotides. We recently demonstrated silencing miRNA function in mice using chemically modified and chole...

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Bibliographic Details
Main Authors: Krützfeldt, Jan, Kuwajima, Satoru, Braich, Ravi, Rajeev, Kallanthottathil G., Pena, John, Tuschl, Thomas, Manoharan, Muthiah, Stoffel, Markus
Format: Online
Language:English
Published: Oxford University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888827/

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