Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies

Human B cells that coexpress surrogate and conventional light chains (V-preB+L+) show an unusual heavy and light chain antibody repertoire that display evidence of receptor editing. However, it is unclear whether V-preB+L+ B cells have been silenced by receptor editing or still express autoreactive...

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Bibliographic Details
Main Authors: Meffre, Eric, Schaefer, Anne, Wardemann, Hedda, Wilson, Patrick, Davis, Eric, Nussenzweig, Michel C.
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887722/