Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice

Heavy chain–only antibodies are spontaneously produced in light chain–deficient mice

In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H chain in the endoplasmic reticulum. Camelids are an exception, expressing homodimeric IgGs, an antibody type that to date has not been found...

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Bibliographic Details
Main Authors: Zou, Xiangang, Osborn, Michael J., Bolland, Daniel J., Smith, Jennifer A., Corcos, Daniel, Hamon, Maureen, Oxley, David, Hutchings, Amanda, Morgan, Geoff, Santos, Fatima, Kilshaw, Peter J., Taussig, Michael J., Corcoran, Anne E., Brüggemann, Marianne
Format: Online
Language:English
Published: The Rockefeller University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150980/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2150980/

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