Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG repair. To test this hypothesis, this study investigated 14 AD patients and 10 age-matched controls for mutations of the major 8-oxoG remov...

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Bibliographic Details
Main Authors: Mao, Guogen, Pan, Xiaoyu, Zhu, Bei-Bei, Zhang, Yanbin, Yuan, Fenghua, Huang, Jian, Lovell, Mark A., Lee, Maxwell P., Markesbery, William R., Li, Guo-Min, Gu, Liya
Format: Online
Language:English
Published: Oxford University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885677/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885677/

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