Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

A series of antisense oligonucleotides (ASOs) containing either 2′-O-methoxyethylribose (MOE) or locked nucleic acid (LNA) modifications were designed to investigate whether LNA antisense oligonucleotides (ASOs) have the potential to improve upon MOE based ASO therapeutics. Some, but not all, LNA co...

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Bibliographic Details
Main Authors: Swayze, Eric E., Siwkowski, Andrew M., Wancewicz, Edward V., Migawa, Michael T., Wyrzykiewicz, Tadeusz K., Hung, Gene, Monia, Brett P., Bennett, and C. Frank
Format: Online
Language:English
Published: Oxford University Press 2007
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802611/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802611/

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