The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis

Clonal expansion of CD4+CD28- T cells is a characteristic finding in patients with rheumatoid arthritis (RA). Expanded CD4+ clonotypes are present in the peripheral blood, infiltrate into the joints, and persist for years. CD4+CD28- T cells are oligoclonal lymphocytes that are rare in healthy indivi...

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Main Authors:	Pawlik, Andrzej, Ostanek, Lidia, Brzosko, Iwona, Brzosko, Marek, Masiuk, Marek, Machalinski, Boguslaw, Gawronska-Szklarz, Barbara
Format:	Online
Language:	English
Published:	BioMed Central 2003
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165060/

id	pubmed-165060
recordtype	oai_dc
spelling	pubmed-1650602003-07-12 The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis Pawlik, Andrzej Ostanek, Lidia Brzosko, Iwona Brzosko, Marek Masiuk, Marek Machalinski, Boguslaw Gawronska-Szklarz, Barbara Research Article Clonal expansion of CD4+CD28- T cells is a characteristic finding in patients with rheumatoid arthritis (RA). Expanded CD4+ clonotypes are present in the peripheral blood, infiltrate into the joints, and persist for years. CD4+CD28- T cells are oligoclonal lymphocytes that are rare in healthy individuals but are found in high percentages in patients with chronic inflammatory diseases. The size of the peripheral blood CD4+CD28- T-cell compartment was determined in 42 patients with RA and 24 healthy subjects by two-color FACS analysis. The frequency of CD4+CD28- T cells was significantly higher in RA patients than in healthy subjects. Additionally, the number of these cells was significantly higher in patients with extra-articular manifestations and advanced joint destruction than in patients with limited joint manifestations. The results suggest that the frequency of CD4+CD28- T cells may be a marker correlating with extra-articular manifestations and joint involvement. BioMed Central 2003 2003-05-14 /pmc/articles/PMC165060/ /pubmed/12823856 http://dx.doi.org/10.1186/ar766 Text en Copyright © 2003 Pawlik et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pawlik, Andrzej Ostanek, Lidia Brzosko, Iwona Brzosko, Marek Masiuk, Marek Machalinski, Boguslaw Gawronska-Szklarz, Barbara
spellingShingle	Pawlik, Andrzej Ostanek, Lidia Brzosko, Iwona Brzosko, Marek Masiuk, Marek Machalinski, Boguslaw Gawronska-Szklarz, Barbara The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
author_facet	Pawlik, Andrzej Ostanek, Lidia Brzosko, Iwona Brzosko, Marek Masiuk, Marek Machalinski, Boguslaw Gawronska-Szklarz, Barbara
author_sort	Pawlik, Andrzej
title	The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
title_short	The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
title_full	The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
title_fullStr	The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
title_full_unstemmed	The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis
title_sort	expansion of cd4+cd28- t cells in patients with rheumatoid arthritis
description	Clonal expansion of CD4+CD28- T cells is a characteristic finding in patients with rheumatoid arthritis (RA). Expanded CD4+ clonotypes are present in the peripheral blood, infiltrate into the joints, and persist for years. CD4+CD28- T cells are oligoclonal lymphocytes that are rare in healthy individuals but are found in high percentages in patients with chronic inflammatory diseases. The size of the peripheral blood CD4+CD28- T-cell compartment was determined in 42 patients with RA and 24 healthy subjects by two-color FACS analysis. The frequency of CD4+CD28- T cells was significantly higher in RA patients than in healthy subjects. Additionally, the number of these cells was significantly higher in patients with extra-articular manifestations and advanced joint destruction than in patients with limited joint manifestations. The results suggest that the frequency of CD4+CD28- T cells may be a marker correlating with extra-articular manifestations and joint involvement.
publisher	BioMed Central
publishDate	2003
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165060/
_version_	1611367060021968896

The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis

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