The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus
In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high-affinity autoantibodies via somatic hypermutati...
| Main Authors: | , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2003
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC165037/ |