The nuclear receptor transcriptional coregulator RIP140

The nuclear receptor superfamily comprises ligand-regulated transcription factors that control various developmental and physiological pathways. These receptors share a common modular structure and regulate gene expression through the recruitment of a large set of coregulatory proteins. These transc...

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Main Authors:	Augereau, Patrick, Badia, Eric, Carascossa, Sophie, Castet, Audrey, Fritsch, Samuel, Harmand, Pierre-Olivier, Jalaguier, Stéphan, Cavaillès, Vincent
Format:	Online
Language:	English
Published:	The Nuclear Receptor Signaling Atlas 2006
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1630689/

id	pubmed-1630689
recordtype	oai_dc
spelling	pubmed-16306892006-11-06 The nuclear receptor transcriptional coregulator RIP140 Augereau, Patrick Badia, Eric Carascossa, Sophie Castet, Audrey Fritsch, Samuel Harmand, Pierre-Olivier Jalaguier, Stéphan Cavaillès, Vincent Review The nuclear receptor superfamily comprises ligand-regulated transcription factors that control various developmental and physiological pathways. These receptors share a common modular structure and regulate gene expression through the recruitment of a large set of coregulatory proteins. These transcription cofactors regulate, either positively or negatively, chromatin structure and transcription initiation. One of the first proteins to be identified as a hormone-recruited cofactor was RIP140. Despite its recruitment by agonist-liganded receptors, RIP140 exhibits a strong transcriptional repressive activity which involves several inhibitory domains and different effectors. Interestingly, the RIP140 gene, located on chromosome 21 in humans, is finely regulated at the transcriptional level by various nuclear receptors. In addition, the protein undergoes several post-translational modifications which control its repressive activity. Finally, experiments performed in mice devoid of the RIP140 gene indicate that this transcriptional cofactor is essential for female fertility and energy homeostasis. RIP140 therefore appears to be an important modulator of nuclear receptor activity which could play major roles in physiological processes and hormone-dependent diseases. The Nuclear Receptor Signaling Atlas 2006-10-30 /pmc/articles/PMC1630689/ /pubmed/17088940 http://dx.doi.org/10.1621/nrs.04024 Text en Copyright © 2006, Augereau et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Augereau, Patrick Badia, Eric Carascossa, Sophie Castet, Audrey Fritsch, Samuel Harmand, Pierre-Olivier Jalaguier, Stéphan Cavaillès, Vincent
spellingShingle	Augereau, Patrick Badia, Eric Carascossa, Sophie Castet, Audrey Fritsch, Samuel Harmand, Pierre-Olivier Jalaguier, Stéphan Cavaillès, Vincent The nuclear receptor transcriptional coregulator RIP140
author_facet	Augereau, Patrick Badia, Eric Carascossa, Sophie Castet, Audrey Fritsch, Samuel Harmand, Pierre-Olivier Jalaguier, Stéphan Cavaillès, Vincent
author_sort	Augereau, Patrick
title	The nuclear receptor transcriptional coregulator RIP140
title_short	The nuclear receptor transcriptional coregulator RIP140
title_full	The nuclear receptor transcriptional coregulator RIP140
title_fullStr	The nuclear receptor transcriptional coregulator RIP140
title_full_unstemmed	The nuclear receptor transcriptional coregulator RIP140
title_sort	nuclear receptor transcriptional coregulator rip140
description	The nuclear receptor superfamily comprises ligand-regulated transcription factors that control various developmental and physiological pathways. These receptors share a common modular structure and regulate gene expression through the recruitment of a large set of coregulatory proteins. These transcription cofactors regulate, either positively or negatively, chromatin structure and transcription initiation. One of the first proteins to be identified as a hormone-recruited cofactor was RIP140. Despite its recruitment by agonist-liganded receptors, RIP140 exhibits a strong transcriptional repressive activity which involves several inhibitory domains and different effectors. Interestingly, the RIP140 gene, located on chromosome 21 in humans, is finely regulated at the transcriptional level by various nuclear receptors. In addition, the protein undergoes several post-translational modifications which control its repressive activity. Finally, experiments performed in mice devoid of the RIP140 gene indicate that this transcriptional cofactor is essential for female fertility and energy homeostasis. RIP140 therefore appears to be an important modulator of nuclear receptor activity which could play major roles in physiological processes and hormone-dependent diseases.
publisher	The Nuclear Receptor Signaling Atlas
publishDate	2006
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1630689/
_version_	1611390338335768576

The nuclear receptor transcriptional coregulator RIP140

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