Replicative DNA polymerases
Replicative DNA polymerases are essential for the replication of the genomes of all living organisms. On the basis of sequence similarities they can be classified into three types. Type A polymerases are homologous to bacterial polymerases I, Type B comprises archaebacterial DNA polymerases and euka...
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| Format: | Online |
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BioMed Central
2001
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150442/ |
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pubmed-150442 |
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pubmed-1504422003-03-07 Replicative DNA polymerases Albà, M Mar Protein Family Review Replicative DNA polymerases are essential for the replication of the genomes of all living organisms. On the basis of sequence similarities they can be classified into three types. Type A polymerases are homologous to bacterial polymerases I, Type B comprises archaebacterial DNA polymerases and eukaryotic DNA polymerase α, and the bacterial polymerase III class make up type C. Structures have been solved for several type A and B polymerases, which share a similar architecture. The structure of type C is not yet known. The catalytic mechanism of all three types involves two metal-ion-binding acidic residues in the active site. Replicative polymerases are constitutively expressed, but their activity is regulated through the cell cycle and in response to different growth conditions. BioMed Central 2001 2001-01-12 /pmc/articles/PMC150442/ /pubmed/11178285 Text en Copyright © 2001 BioMed Central Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Albà, M Mar |
| spellingShingle |
Albà, M Mar Replicative DNA polymerases |
| author_facet |
Albà, M Mar |
| author_sort |
Albà, M Mar |
| title |
Replicative DNA polymerases |
| title_short |
Replicative DNA polymerases |
| title_full |
Replicative DNA polymerases |
| title_fullStr |
Replicative DNA polymerases |
| title_full_unstemmed |
Replicative DNA polymerases |
| title_sort |
replicative dna polymerases |
| description |
Replicative DNA polymerases are essential for the replication of the genomes of all living organisms. On the basis of sequence similarities they can be classified into three types. Type A polymerases are homologous to bacterial polymerases I, Type B comprises archaebacterial DNA polymerases and eukaryotic DNA polymerase α, and the bacterial polymerase III class make up type C. Structures have been solved for several type A and B polymerases, which share a similar architecture. The structure of type C is not yet known. The catalytic mechanism of all three types involves two metal-ion-binding acidic residues in the active site. Replicative polymerases are constitutively expressed, but their activity is regulated through the cell cycle and in response to different growth conditions. |
| publisher |
BioMed Central |
| publishDate |
2001 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150442/ |
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1611366619704983552 |