DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

Infection of T cells by HIV-1 can occur through binding of virus to dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) on dendritic cells and transfer of virus to CD4+ T cells. Here we show that a subset of B cells in the blood and tonsils of normal donors expressed DC-SIGN, and that...

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Bibliographic Details
Main Authors: Rappocciolo, Giovanna, Piazza, Paolo, Fuller, Craig L, Reinhart, Todd A, Watkins, Simon C, Rowe, David T, Jais, Mariel, Gupta, Phalguni, Rinaldo, Charles R
Format: Online
Language:English
Published: Public Library of Science 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500807/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500807/

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