Bioactivation and covalent binding of halothane to liver macromolecules.
In this manuscript we report our attempts to determine if 14C-halothane or its metabolites interact with DNA. Three bioactivation systems were used: in vitro microsomal incubations, isolated hepatocytes, and in vivo administration. Even though we used optimal conditions for bioactivation, no signifi...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
1977
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475325/ |