Structure-activity relationships for ulcerogenic and adrenocorticolytic effects of alkyl nitriles, amines, and thiols.
In rats, a single administration of acrylonitrile (vinyl cyanide) produces a rapidly occurring bilateral adrenal apoplexy. Structure-activity studies have shown that a close derivative, propionitrile (ethyl cyanide), causes duodenal ulcer without markedly affecting the adrenal glands. Prolonging the...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
1975
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1475202/ |