Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

Spontaneous ovarian tumors are very rare in ACI, Wistar, F344 and Donryu rats; the few neoplasms found are of the granulosa/theca cell type. Ovarian tumors were also rare in these strains of rats when given high doses of N-alkyl-N-nitrosoureas continuously in the drinking water for their life-span;...

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Main Authors:	Maekawa, A, Onodera, H, Tanigawa, H, Furuta, K, Kanno, J, Ogiu, T, Hayashi, Y
Format:	Online
Language:	English
Published:	1987
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474567/

id	pubmed-1474567
recordtype	oai_dc
spelling	pubmed-14745672006-06-09 Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas. Maekawa, A Onodera, H Tanigawa, H Furuta, K Kanno, J Ogiu, T Hayashi, Y Research Article Spontaneous ovarian tumors are very rare in ACI, Wistar, F344 and Donryu rats; the few neoplasms found are of the granulosa/theca cell type. Ovarian tumors were also rare in these strains of rats when given high doses of N-alkyl-N-nitrosoureas continuously in the drinking water for their life-span; however, relatively high incidences of Sertoli cell tumors or Sertoli cell tumors mixed with granulosa cell tumors were induced in Donryu rats after administration of either a 400 ppm N-ethyl-N-nitrosourea solution in the drinking water for 4 weeks or as a single dose of 200 mg N-propyl-N-nitrosourea per kg body weight by stomach tube. Typical Sertoli cell tumors consisted of solid areas showing tubular formation. The tubules were lined by tall, columnar cells, with abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented, round nuclei, resembling seminiferous tubules in the testes. In some cases, Sertoli cell tumor elements were found mixed with areas of granulosa cells. The induction of ovarian Sertoli cell tumors in Donryu rats by low doses of nitrosoureas may provide a useful model for these tumors in man. 1987-08 /pmc/articles/PMC1474567/ /pubmed/3665856 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Maekawa, A Onodera, H Tanigawa, H Furuta, K Kanno, J Ogiu, T Hayashi, Y
spellingShingle	Maekawa, A Onodera, H Tanigawa, H Furuta, K Kanno, J Ogiu, T Hayashi, Y Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.
author_facet	Maekawa, A Onodera, H Tanigawa, H Furuta, K Kanno, J Ogiu, T Hayashi, Y
author_sort	Maekawa, A
title	Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.
title_short	Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.
title_full	Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.
title_fullStr	Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.
title_full_unstemmed	Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.
title_sort	experimental induction of ovarian sertoli cell tumors in rats by n-nitrosoureas.
description	Spontaneous ovarian tumors are very rare in ACI, Wistar, F344 and Donryu rats; the few neoplasms found are of the granulosa/theca cell type. Ovarian tumors were also rare in these strains of rats when given high doses of N-alkyl-N-nitrosoureas continuously in the drinking water for their life-span; however, relatively high incidences of Sertoli cell tumors or Sertoli cell tumors mixed with granulosa cell tumors were induced in Donryu rats after administration of either a 400 ppm N-ethyl-N-nitrosourea solution in the drinking water for 4 weeks or as a single dose of 200 mg N-propyl-N-nitrosourea per kg body weight by stomach tube. Typical Sertoli cell tumors consisted of solid areas showing tubular formation. The tubules were lined by tall, columnar cells, with abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented, round nuclei, resembling seminiferous tubules in the testes. In some cases, Sertoli cell tumor elements were found mixed with areas of granulosa cells. The induction of ovarian Sertoli cell tumors in Donryu rats by low doses of nitrosoureas may provide a useful model for these tumors in man.
publishDate	1987
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474567/
_version_	1611383466941743104

Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

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