Cellular and molecular mechanisms of multistep carcinogenesis: relevance to carcinogen risk assessment.
Carcinogenesis is a multistep process involving alterations in at least two distinct classes of genes. Protooncogenes are activated qualitatively or quantitatively in certain tumors, and they appear to act as positive proliferative signals for neoplastic growth. In contrast, tumor suppressor genes a...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
1987
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474467/ |