Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system

Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system

Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional phagocytes, and cause abortion in domestic animals and undulant fever in humans. Several species are recognized within the genus Brucella and this classification i...

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Main Authors: Cardoso, Patrícia Gomes, Macedo, Gilson Costa, Azevedo, Vasco, Oliveira, Sergio Costa
Format: Online
Language:English
Published: BioMed Central 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435926/
id pubmed-1435926
recordtype oai_dc
spelling pubmed-14359262006-04-14 Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system Cardoso, Patrícia Gomes Macedo, Gilson Costa Azevedo, Vasco Oliveira, Sergio Costa Review Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional phagocytes, and cause abortion in domestic animals and undulant fever in humans. Several species are recognized within the genus Brucella and this classification is mainly based on the difference in pathogenicity and in host preference. Brucella strains may occur as either smooth or rough, expressing smooth LPS (S-LPS) or rough LPS (R-LPS) as major surface antigen. This bacterium possesses an unconventional non-endotoxic lipopolysaccharide that confers resistance to anti-microbial attacks and modulates the host immune response. The strains that are pathogenic for humans (B. abortus, B. suis, B. melitensis) carry a smooth LPS involved in the virulence of these bacteria. The LPS O-chain protects the bacteria from cellular cationic peptides, oxygen metabolites and complement-mediated lysis and it is a key molecule for Brucella survival and replication in the host. Here, we review i) Brucella LPS structure; ii) Brucella genome, iii) genes involved in LPS biosynthesis; iv) the interaction between LPS and innate immunity. BioMed Central 2006-03-23 /pmc/articles/PMC1435926/ /pubmed/16556309 http://dx.doi.org/10.1186/1475-2859-5-13 Text en Copyright © 2006 Cardoso et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Cardoso, Patrícia Gomes
Macedo, Gilson Costa
Azevedo, Vasco
Oliveira, Sergio Costa
spellingShingle Cardoso, Patrícia Gomes
Macedo, Gilson Costa
Azevedo, Vasco
Oliveira, Sergio Costa
Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system
author_facet Cardoso, Patrícia Gomes
Macedo, Gilson Costa
Azevedo, Vasco
Oliveira, Sergio Costa
author_sort Cardoso, Patrícia Gomes
title Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system
title_short Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system
title_full Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system
title_fullStr Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system
title_full_unstemmed Brucella spp noncanonical LPS: structure, biosynthesis, and interaction with host immune system
title_sort brucella spp noncanonical lps: structure, biosynthesis, and interaction with host immune system
description Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in professional and non-professional phagocytes, and cause abortion in domestic animals and undulant fever in humans. Several species are recognized within the genus Brucella and this classification is mainly based on the difference in pathogenicity and in host preference. Brucella strains may occur as either smooth or rough, expressing smooth LPS (S-LPS) or rough LPS (R-LPS) as major surface antigen. This bacterium possesses an unconventional non-endotoxic lipopolysaccharide that confers resistance to anti-microbial attacks and modulates the host immune response. The strains that are pathogenic for humans (B. abortus, B. suis, B. melitensis) carry a smooth LPS involved in the virulence of these bacteria. The LPS O-chain protects the bacteria from cellular cationic peptides, oxygen metabolites and complement-mediated lysis and it is a key molecule for Brucella survival and replication in the host. Here, we review i) Brucella LPS structure; ii) Brucella genome, iii) genes involved in LPS biosynthesis; iv) the interaction between LPS and innate immunity.
publisher BioMed Central
publishDate 2006
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1435926/
_version_ 1611381894084034560

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