Hormonal control of p53 and chemoprevention
Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of menarche, and age at menopause are major risk factors drawing attention to the important role of the en...
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| Format: | Online |
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BioMed Central
2002
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138728/ |
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pubmed-1387282003-02-27 Hormonal control of p53 and chemoprevention Jerry, D Joseph Minter, Lisa M Becker, Klaus A Blackburn, Anneke C Commentary Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of menarche, and age at menopause are major risk factors drawing attention to the important role of the endocrine system in determining the risk of breast cancer, while heritable breast cancer susceptibility syndromes have implicated tumor suppressor genes as important targets. Recent work demonstrating hormonal modulation of the p53 tumor suppressor pathway draws together these established determinants of risk to provide a model of developmental susceptibility to breast cancer. In this model, the mammary epithelium is rendered susceptible due to impaired p53 activity during specific periods of mammary gland development, but specific endocrine stimuli serve to activate p53 function and to mitigate this risk. The results focus attention on p53 as a molecular target for therapies to reduce the risk of breast cancer. BioMed Central 2002 2002-03-26 /pmc/articles/PMC138728/ /pubmed/12052250 http://dx.doi.org/10.1186/bcr431 Text en Copyright © 2002 BioMed Central Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jerry, D Joseph Minter, Lisa M Becker, Klaus A Blackburn, Anneke C |
| spellingShingle |
Jerry, D Joseph Minter, Lisa M Becker, Klaus A Blackburn, Anneke C Hormonal control of p53 and chemoprevention |
| author_facet |
Jerry, D Joseph Minter, Lisa M Becker, Klaus A Blackburn, Anneke C |
| author_sort |
Jerry, D Joseph |
| title |
Hormonal control of p53 and chemoprevention |
| title_short |
Hormonal control of p53 and chemoprevention |
| title_full |
Hormonal control of p53 and chemoprevention |
| title_fullStr |
Hormonal control of p53 and chemoprevention |
| title_full_unstemmed |
Hormonal control of p53 and chemoprevention |
| title_sort |
hormonal control of p53 and chemoprevention |
| description |
Improvements in the detection and treatment of breast cancer have dramatically altered its clinical course and outcome. However, prevention of breast cancer remains an elusive goal. Parity, age of menarche, and age at menopause are major risk factors drawing attention to the important role of the endocrine system in determining the risk of breast cancer, while heritable breast cancer susceptibility syndromes have implicated tumor suppressor genes as important targets. Recent work demonstrating hormonal modulation of the p53 tumor suppressor pathway draws together these established determinants of risk to provide a model of developmental susceptibility to breast cancer. In this model, the mammary epithelium is rendered susceptible due to impaired p53 activity during specific periods of mammary gland development, but specific endocrine stimuli serve to activate p53 function and to mitigate this risk. The results focus attention on p53 as a molecular target for therapies to reduce the risk of breast cancer. |
| publisher |
BioMed Central |
| publishDate |
2002 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138728/ |
| _version_ |
1611366201817038848 |