Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?
The human p53 tumor suppressor gene TP53 is mutated at a high frequency in sporadic breast cancer, and Li-Fraumeni syndrome patients who carry germline mutations in one TP53 allele have a high incidence of breast cancer. In the 10 years since the first knockout of the mouse p53 tumor suppressor gene...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2002
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138724/ |