Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?
Brca1 is involved in multiple biological pathways including DNA damage repair, transcriptional regulation, and cell-cycle progression. A complex pattern of interactions of Brca1 with Trp53 has also emerged. Xu and coworkers found that haploid loss of Trp53 significantly reduces the embryonic lethali...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2002
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138719/ |