High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer

High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer

Cell surface mannose 6-phosphate/insulin-like growth factor II receptors (M6P/IGF2R) bind and target exogenous insulin-like growth factor II (IGF2) to the prelysosomes where it is degraded. Loss of heterozygosity (LOH) for M6P/IGF2R is found in cancers, with mutational inactivation of the remaining...

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Bibliographic Details
Main Authors: Huang, Zhiqing, Wen, Yaqing, Shandilya, Ruby, Marks, Jeffrey R., Berchuck, Andrew, Murphy, Susan K.
Format: Online
Language:English
Published: Oxford University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1345698/

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